Tableau Recapitulatif - Les Laboratoires TEOXANE

SCIENTIFIC INFORMATION / CARACTERISTICS

Characteristics / Benefits

TEOSYAL EFFECTIVE-SAFE-LONG-LASTING
CHARACTERISTICS	BENEFITS
1. Safe, high-quality products.	1 < 15 000 cases of temporary local side-effects at the site of the injection (out of 1 500 000 injections carried out)*.
2. Ergonomic glass, syringe with very accurate graduations (0.025 ml), 360° swivel base.	Short and easy to use for a highly viscous product. Painless injection, controls the quantity injected, excellent control of injection.
3. 25 mg/g concentration: one of the highest on the market.	High durability and viscosity: effective and lasting filling effect.
4. Protein content: less than 5 µg/g**.	Limited risk of hypersensitivity ⁽¹²⁾.
5. Bacterial endotoxin content: far lower than European Pharmacopeia requirements***.	Low risk of inflammation: limited action of free radicals, the main factors involved in the breakdown of hyaluronic acid.
6. Single-phase, homogeneous gel.	Reduced sensitivity to free radicals slows down breakdown ^{(13), (14)}.
7. Packaging: 2 1ml syringes, blister packaged.	More product for better results.

*Data as of March 2010.
**Manufacturer's data
***European Pharmacopeia specifications(Current edition) require hyaluronic acid-based gels with a concentration of 25 mg/g (such as Teosyal®) to have a bacterial endotoxin level of less than 12.5 EU/g (E.U. = Endotoxin Unit). The bacterial endotoxin content is measured on each batch of Teosyal®. Value measured on 30 consecutive batches: <0.2 EU/g.
Measurements taken by an independent GLP-certified laboratory by the AFFSaPS, Swissmedic and the FDA.