Deciphering degradation dynamics: assessing the reversibility of Hyaluronic Acid fillers

Hyaluronic acid (HA)-based dermal fillers are widely used in cosmetic medicine to rejuvenate facial appearance and address soft tissue aging. The optimal use of these fillers requires a delicate balance between achieving aesthetic enhancements and ensuring safety and durability. Understanding the degradation characteristics of different HA fillers, particularly in response to hyaluronidase, is crucial for managing adverse events effectively.

In a new study, published in the Aesthetic Surgery Journal and conducted by Teoxane’s R&D department, in partnership with Revance, we developed an innovative in vitro rheological method to analyze the degradation of 16 commercially available HA fillers following exposure to hyaluronidase. These fillers, representing various manufacturing technologies and indications, were assessed for their physicochemical properties and rheological characteristics.

The study revealed that the manufacturing technology of HA fillers significantly influences their degradation profile, surpassing the impact of individual parameters such as HA concentration or chain length. Notably, fillers manufactured with Teoxane’s Preserved Network Technology (PNT) demonstrated a consistent degradation profile, with variations attributed to progressive crosslinking and HA concentration within the product line, offering insights into their reversibility.

This study underscores the importance of considering filler manufacturing technology in assessing the reversibility of HA-based fillers and provides valuable insights into the real-world clinical use of hyaluronidase.