New Expert Review Provides Guidance on Safe and Effective Infraorbital Hollow Rejuvenation

Teoxane proudly announces the publication of a new comprehensive review in Aesthetic Surgery Journal Open Forum highlighting best practices for the safe and effective use of hyaluronic acid (HA) fillers in treating infraorbital hollows (IOH).

Infraorbital hollows, which include the tear trough and palpebromalar groove, are a key focus in facial rejuvenation, as they strongly influence perceived age and expression. The review provides a complete overview of anatomy, injection techniques, and product selection criteria to help practitioners achieve natural-looking results while minimizing risks.

This study provides a comprehensive approach to infraorbital hollow rejuvenation, emphasizing anatomical knowledge and tailored injection strategies. By addressing midface volume loss and using advanced HA fillers, clinicians can deliver safe treatments with natural results.

Key insights from the review

• HA fillers are effective in reducing infraorbital hollows and smoothing the eyelid–cheek junction, restoring a youthful, refreshed appearance.
• Anatomical knowledge is essential: the review details changes caused by aging (bone resorption, fat atrophy, skin thinning) and maps neurovascular structures such as the angular and infraorbital arteries to avoid complications.
• Aging also affects lymphatic drainage, contributing to puffiness and fluid accumulation in the periorbital area.
• Treatment strategies: indirect techniques (midface volumization and lifting) should often precede direct injection into the infraorbital area for optimal results.
• Product selection matters: fillers should be smooth, malleable, and have limited hygroscopicity to reduce edema risk and ensure natural outcomes.

Clinical relevance

By combining anatomical precision with thoughtful filler selection, practitioners can optimize safety and patient satisfaction in infraorbital hollow treatments. The review underscores the value of a comprehensive patient assessment and individualized treatment planning to achieve results that are both effective and natural-looking.