About Hyaluronic Acid

About Hyaluronic Acid

What is Hyaluronic Acid (HA)?


Hyaluronic acid (HA) is a substance made up of a long chain of sugar molecules strung together like a necklace. It is naturally found in many areas of your body,1 where it acts as a “water-binding” molecule that lubricates and protects your tissues.2 It is what gives your skin structure and is responsible for that plump and hydrated look.

What is its role?

Hyaluronic acid (HA) is one of the main elements of the extracellular matrix (ECM): a matrix that creates spaces between cells and acts as a scaffold to all living cells. It is the ECM that determines how our tissues look and work.2-4

When it comes to HA, size matters.3

High molecular weight HA (HMW-HA) is the most beneficial for skin as it is able to bind larger amounts of water. 2 

HMW-HA therefore provides good lubrication, hydration, and space-filling properties for tissues, important characteristics for injectables and skin products.3,4

On the other hand, if the molecular weight of HA is too low, it may cause inflammation.3

Hyaluronic acid plays a critical role in skin health by stimulating the production of cells called fibroblasts.3,6 Fibroblasts are in turn responsible for producing collagen and elastin.6 Thus hyaluronic acid provides desired levels of hydration and elasticity while keeping the skin firm and supple.5It also acts as an antioxidant, protecting our cells from damage and therefore allowing the ECM to function correctly (for example, in wound healing).7

What is Hyaluronic Acid (HA)?

Hyaluronic acid is widely used as an active ingredient in many beauty products. 5

HA fillers are used to reduce wrinkles, to model cheeks and to improve elasticity and hydration of skin on the face, neck, and neckline. In creams and serums, HA is used to act as a protective barrier, allowing the skin to retain moisture, for a plumped, hydrated look. 5

Hyaluronic acid is widely used in many beauty products

Teoxane is a Swiss designer and manufacturer of hyaluronic acid based injectables and skincare ranges.  

Always at the forefront of innovation, we have created TEOSYAL RHA®, the first range of HA fillers with dynamic properties specifically designed to follow facial expressions.8

TEOSYAL  RHA®, designed for facial dynamics 


When a dermal filler is injected into the face, it is subjected to a wide range of facial movements and pressures that occur when you express emotions, talk, eat….1

These can alter the properties and behaviour of the filler. 

Fillers need to be designed with facial dynamics in mind, so they seamlessly follow our facial expressions and resist deformations and pressures from skin layers for natural and long-lasting results.2,3

This is where Teoxane comes in. 

Teoxane is the first aesthetics company to put facial movement at the heart of its product design and testing, with its new range of dynamic premium fillers*, Teosyal RHA® by Teoxane. 

This is the first collection of dermal fillers* indicated for dynamic wrinkles and folds and adapted to the mobile regions of the face.

TEOSYAL RHA® vs HA: what’s the difference? 

What sets TEOSYAL RHA® apart




Due to a unique and bespoke manufacturing process, the preserved network technology1, TEOSYAL RHA® has longer chains and less rigid crosslinks than the modified HA usually found in dermal fillers.1 

This mobile structure, closer to natural HA than other modified HA found in traditional fillers, confers unique dynamic properties to the TEOSYAL RHA® fillers4


  • SUPPLENESS, to adapt faster to facial movement and preserve natural facial expressions 


  • RESISTANCE, to repeatedly bounce back from deep muscle pressures for long-lasting volume 


  • STRUCTURAL INTEGRITY, to withstand facial stresses without fragmenting for predictable results with no irregularities.
TEOSYAL RHA®  unique dynamic properties

TEOSYAL RHA® fillers seamlessly follow the movement of the face and enhances individual's unique natural expressions without erasing what makes them who they are.2,4

The versatility of the TEOSYAL RHA® range 

Each filler within the TEOSYAL RHA® line (RHA® 1, RHA® 2, RHA® 3, RHA® 4 or RHA KISS®) benefits from a unique combination of suppleness and resistance, to meet the specific aesthetic needs of different dynamic facial regions.1 

From one of the supplest fillers on the market (RHA® 1) 1** for superficial dynamic wrinkle correction 

To one of the most resistant volumizers on the market (RHA® 4) 1*** for volume restoration and deep facial wrinkle and folds. 

TEOSYAL RHA® line (RHA® 1, RHA® 2, RHA® 3, RHA® 4 or RHA KISS®)

The versatility of the TEOSYAL RHA® line allows doctors to confidently inject the right product (or combination of products) at the right depth and location with the right technique to provide natural, tailored results for each patient4.

Find out more about the TEOXANE APPROACH 

Find our more about our Teosyal RHA® line

The clinical benefits of TEOSYAL RHA® 

The clinical efficacy and safety of the RHA® range was proven in an 12-month comparative study5**** (up to 18 months for RHA®2, RHA® 3 and RHA® 44*****). 

These studies demonstrated excellent immediate and long-lasting efficacy. It also highlighted the increased satisfaction of both patients and doctors with results vs other commercially available fillers used, as well as the ease of injection and improved product positioning experienced by doctors. 4,5

These award-winning fillers move in harmony with facial expressions to provide a natural looking result, whilst remaining undetectable.4,5


An innovative crosslinking technique 

Classical method

During conventional filler manufacturing processes, the natural chains and bonds of HA are fragmented due to these harsh conditions. These chains must then be brought back together with rigid crosslinks, creating a brittle structure that no longer flows with movement.1

Classical Method

Preserved Network Technology

Inspired by human biology, Teoxane has developed the unique “preserved network technology” 1 that, as its name suggests, better preserves the long chains and mobile bonds of natural hyaluronic acid, thus allowing minimal modification.1

Teoxane Preserved Network Technology