Hyaluronic Acid

Hyaluronic Acid

What is hyaluronic acid and what are the differences between hyaluronic acid and botulinum toxin?5,7,19

Hyaluronic acid (HA) is a naturally occurring substance that is found in all living organisms. Nearly 50% of the total HA in the body is found in the skin, where it provides moisture. Indeed, hyaluronic acid is an excellent natural moisturiser that has the impressive quality of being able to attract and hold up to 1,000 times its own weight in water. It also stimulates the production of collagen and elastin, boosting the volume and plumpness of your skin. Essentially, it is the key to giving your skin a fuller look and feel. And because it is naturally present in our body, hyaluronic acid is non-toxic, non-irritating and non-allergenic.4,7,15,17,18

  • Hyaluronic Acid
  • VS
  • Botulinium toxin
  • Hyaluronic Acid

    Hyaluronic acid

  • VS
  • Botulinium toxin

    Botulinium toxin

  • Where is it found? 

  • BT1

    It exists naturally in the skin

  • bt2

    It is producted by a bacterium called Clostridium botulinum

  • Where is it injected?

  • ha2

    The dermal filler* is injected into the dermis or subcutaneous layer, under the skin

  • bt3

    The preparation of botulinum toxin is injected directly into muscles

  • What effect does it have?

  • ha3

    Improves skin quality, replaces lost volume, defines facial contours and repairs facial imperfections

  • BT3

    It removes lines and wrinkles caused by muscle contractions. It has no plumping or smoothing effect

*Dermal fillers contain modified HA.

Nevertheless, because they work in different ways, many people choose to have both dermal fillers and botulinum toxin injections: the combination can produce a remarkably younger-looking face.20,21


4. Baumann L. Skin ageing and its treatment. J Pathol. 2007;211(2):241-51

5. Emre IE, Cakmak O. Ageing face, an overview – Aetiology, assessment and management. Otorhinolaryngol. 2013;6(3):160-6

15. Olejnik, A., Goscianska, J. and Nowak, I. Significance of hyaluronic acid in cosmetic industry and aesthetic medicine. Chemik 66, 129–135 (2012)

17. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin ageing. Dermatoendocrinol. 2012 Jul 1;4(3):253-8

18. Fida M, Dervishi O, Pupo L, Bezati B, Lashi E, Vasili E. Aesthetic dermatology today. Int J Sci Res. 2015;4(10):1799-803

19. Kenner JR. Hyaluronic acid filler and botulinum Neurotoxin delivered simultaneously in the same syringe for effective and convenient combination aesthetic rejuvenation therapy. J Drugs Dermatol. 2010 Sep;9(9):1135-8

20. Coleman KR, Carruthers J. Combination therapy with BOTOX and fillers: the new rejuvnation paradigm. Dermatol Ther. 2006b May-Jun;19(3):177-88

21. Sundaram H, Liew S, Signorini M, et al: Hyaluronic Acid Fillers and Botulinum Toxin Type A-Recommendations for Combined Treatment and Optimizing Outcomes in Diverse Patient Populations. Plast Reconstr Surg. 2016 May;137(5):1410-23

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